![immunoglobulin light chain variable region fragment [Homo sapiens]图片](http://www.cnreagent.com/data/daily/2022/11/05/081140_617894_umcs_1046517.png)
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 864.04 |
| Formula | C40H69N11O10 |
| Synonyms | H2N-Phe-Thr-Leu-Lys-Ile-Ser-Arg-OH |
| Solubility | ≥86.4 mg/mL in DMSO; insoluble in EtOH; ≥14.43 mg/mL in H2O |
| Canonical SMILES | NC(C(NC(C(C)O)C(NC(CC(C)C)C(NC(CCCCN)C(NC(C(C)CC)C(NC(CO)C(NC(CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)=O)CC1=CC=CC=C1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
免疫球蛋白轻链可变区片段序列为Phe-Thr-Leu-Lys-Ile-Ser-Arg，是人免疫球蛋白轻链的可变区的片段。
免疫球蛋白（Ig）是B细胞的抗原识别分子。Ig分子是由2条相同的重链和2条相同的轻链通过二硫键连接，每条重链与对应轻链连接，2条重链连接在一起。每个轻链均有一个可变区和恒定区。可变区的作用是结合抗原。
一条重链的和一条轻链的可变区组成抗体的抗原结合位点。典型的轻链可变区包括105到110个氨基酸，某些位点表现出较多的序列可变性。可变片段是对IgG和IgM类抗体进行酶裂解所得到的最小片段。
Figure1 Diagram of the immunoglobulin structure
Figure 2:Immunoglobulin light chain variable region fragment [Homo sapiens]
参考文献：
1. Janeway CA, Jr et al. (2001).Immunobiology.(5th ed.). Garland Publishing. ISBN 0-8153-3642-X
2. Woof J, Burton D (2004). “Human antibody-Fc receptor interactions illuminated by crystal structures”.Nat Rev Immunol4 (2): 89–99. doi :10.1038/nri1266. PMID 15040582.
3. Mattu T, Pleass R, Willis A, Kilian M, Wormald M, Lellouch A, Rudd P, Woof J, Dwek R (1998). “The glycosylation and structure of human serum IgA1, Fab, and Fc regions and the role of N-glycosylation on Fc alpha receptor interactions”. J Biol Chem 273 (4): 2260–72. doi:10.1074/jbc.273.4.2260. PMID 9442070.
4. Roux K (1999). “Immunoglobulin structure and function as revealed by electron microscopy”.Int Arch Allergy Immunol120 (2): 85–99. doi :10.1159/000024226. PMID 10545762.
5. Barclay A (2003). “Membrane proteins with immunoglobulin-like domains–a master superfamily of interaction molecules”.Semin Immunol15 (4): 215–23. doi :10.1016/S1044-5323(03)00047-2. PMID 14690046 .
6. Putnam FW, Liu YS, Low TL (1979). “Primary structure of a human IgA1 immunoglobulin. IV. Streptococcal IgA1 protease, digestion, Fab and Fc fragments, and the complete amino acid sequence of the alpha 1 heavy chain”.J Biol Chem254 (8): 2865–74. PMID 107164.
7. Huber R (1980). “Spatial structure of immunoglobulin molecules”.Klin Wochenschr58 (22): 1217–31. doi :10.1007/ BF01478928 6780722.
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