| CAS NO: | 98813-13-9 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| Cas No. | 98813-13-9 |
| 别名 | 巴佛洛霉素D |
| 化学名 | (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-[(1S,2R,3S,5E,7S,8R)-2,8-dihydroxy-1,3,7,9-tetramethyl-4-oxo-5-decen-1-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-oxacyclohexadeca-3,5,11,13-tetraen-2-one |
| Canonical SMILES | C[C@H](C(/C=C/[C@H](C)[C@H](O)C(C)C)=O)[C@H](O)[C@@H]([C@](OC(/C(OC)=C/C(C)=C/[C@@H](C)[C@@H](O)[C@@H](C)C1)=O)([H])[C@H](/C=C/C=C1\C)OC)C |
| 分子式 | C35H56O8 |
| 分子量 | 604.8 |
| 溶解度 | Soluble in ethanol;Soluble in methanol;Soluble in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Bafilomycin D is a potent inhibitor of vacuolar H+ ATPases (V-ATPases) with IC50 value of approximately 2 nM for the V-ATPase from the fungus N. crassa [1]. Ion pumps use the energy provided by the hydrolysis of ATP to energize ion-transport processes across cell membranes. ATPases can be distinguished to P-type, F-type and V-type ATPases. P-type ATPases have a phosphorylated transitional stage, F-type ATPases are primarily used in ATP synthesis, and V-type ATPases are genetically and functionally related to F-ATPases but function only in ATP breakdown [1]. The bafilomycins are fungal plecomacrolide class macrolide antibiotics isolated from the culture medium of Streptomyces sp. and are also high-affinity inhibitors of V-ATPases and can be used to study specifically the function of this type of ATPase. They inhibited the growth of Gram-positive bacteria and fungi. Bafilomycin C1 inhibited the enzymatic activity of the Na+, K+-ATPase with Ki value of 11 μmol/l and showed anthelmintic activity against Caenorhabditis elegans [1][2]. References: |
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