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7ACC1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
7ACC1图片
CAS NO:50995-74-9
包装与价格:
包装价格(元)
100mg电议
200mg电议

产品介绍
7ACC1(DEAC;香豆素 D 1421;D 1421)选择性地干扰富含乳酸的肿瘤微环境中的乳酸通量;抑制表达 MCT1 和 MCT4 转运蛋白的肿瘤细胞中的乳酸流入,但不抑制流出。
Cas No.50995-74-9
别名香豆素D1421; DEAC; Coumarin D 1421; D 1421
化学名7-(diethylamino)-2-oxochromene-3-carboxylic acid
Canonical SMILESCCN(CC)C1=CC2=C(C=C1)C=C(C(=O)O2)C(=O)O
分子式C14H15NO4
分子量261.27
溶解度≥ 13.05mg/mL in DMSO
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

7ACC1(DEAC; Coumarin D 1421; D 1421) selectively interfere with lactate fluxes in the lactate-rich tumor microenvironment; inhibits lactate influx but not efflux in tumor cells expressing MCT1 and MCT4 transporters.IC50 value: 0.86 uM(Lactate uptake inhibition) [1]Target: MCT inhibitor; lactate transport inhibitorContrary to the reference MCT1 inhibitor AR-C155858, 7ACC unexpectedly inhibited lactate influx but not efflux in tumor cells expressing MCT1 and MCT4 transporters. 7ACC delayed the growth of cervix SiHa tumors, colorectal HCT116 tumors, and orthoptopic MCF-7 breast tumors. MCT target engagement was confirmed by the lack of activity of 7ACC on bladder UM-UC-3 carcinoma that does not express functional MCT. 7ACC also inhibited SiHa tumor relapse after treatment with cisplatin. Finally, we found that contrary to AR-C155858, 7ACC did not prevent the cell entry of the substrate-mimetic drug 3-bromopyruvate (3BP) through MCT1, and contributed to the inhibition of tumor relapse after 3BP treatment.

References:
[1]. Draoui N, et al. Antitumor activity of 7-aminocarboxycoumarin derivatives, a new class of potent inhibitors of lactate influx but not efflux. Mol Cancer Ther. 2014 Jun;13(6):1410-8.