CAS NO: | 1600543-88-1 |
包装: | 100μg |
市场价: | 4043元 |
Cas No. | 1600543-88-1 |
Canonical SMILES | CCC(C(/N=C(O)/C(N)CSSCC(/N=C(O)/C(N=C(O)C(N=C(O)C1CCCN12)CCCNC(N)=N)CSSCC(/N=C(O)/C(/N=C(O)/C(/N=C(O)/C(/N=C(O)\C(/N=C(O)/C(/N=C(O)/C(/N=C(O)/C(/N=C(O)/C/N=C(O)/C(/N=C(O)/C(/N=C(O)/C(/N=C(O)/C3CCCN34)C(O)C)CC(C)C)CC5=CN=CN5)C(CC)C)CC6=CNC7=CC=CC=C67)CC8=C |
分子式 | C196H292N50O56S6 |
分子量 | 4437.11 |
溶解度 | Soluble to 1 mg/ml in Water |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Huwentoxin XVI(HWTX-XVI ) is composed of 39 amino acid residues including six cysteines. HWTX-XVI is a novel neurotoxin from the venom of Chinese tarantula O. huwena. and specificially block N-type calcium channels. [1] N-type calcium channels are often highly expressed both in dorsal root ganglia cell bodies and in the synaptic terminals projecting to dorsal horn of the spinal cord N-type calcium channels play important roles in the control of neurotransmission release and transmission of pain signals to the central nervous system.[2] Electrophysiological assay indicated that HWTX-XVI specifically inhibited N-type calcium channels in rat dorsal root ganglion cells. HWTX-XVI specifically inhibits GVIA sensitive, N-type calcium channels in rat DRG cells.[1] HWTX-XVI could almost completely block the twitch response of rat vas deferens to low-frequency electrical stimulation. HWTX-XVI ‘s analgesic effects, non-toxic and complete reversibility make it an interesting tool for developing novel drugs for the treatment of N-type calcium channel-related diseases.[1,2] References: |