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GW 4869(hydrochloride hydrate)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
GW 4869(hydrochloride hydrate)图片
CAS NO:6823-69-4
包装与价格：
包装价格(元)
5mg电议
25mg电议

产品介绍

化学性质

StorageStore at -20°C，现配现用
M.Wt595.52
Cas No.6823-69-4
FormulaC30H32Cl2N6O3
Solubilityinsoluble in H2O; insoluble in EtOH; ≥11.92 mg/mL in DMSO with gentle warming
Canonical SMILESO=C(/C=C/C1=CC=C(C=C1)/C=C/C(NC2=CC=C(C=C2)C3=NCCN3)=O)NC4=CC=C(C=C4)C5=NCCN5.Cl.Cl.O
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

GW 4869 (hydrochloride hydrate) is a noncompetitive inhibitor of neutral sphingomyelinase (N-SMase) with an IC50 of 1 μM [1].

N-SMase, one of sphingomyelinases, is involved in sphingomyelin (SM) hydrolysis which is one of two main routes for the generation of ceramide. The sphingolipid ceramide has been shown to induce programmed cell death [1].

GW 4869 was selective for N-SMase, and did not inhibit acid SMase (A-SMase) at up to at least 150 μM. In MCF7 cells, GW 4869 at 10 μM partially inhibited tumor necrosis factor (TNF)-induced SM hydrolysis, and 20 μM of the compound completely protected SM from hydrolysis. The addition of 10 ~ 20 μM GW 4869 completely inhibited the initial accumulation of ceramide, and this effect was only partially lost at later time points (24 h) [1].

In male C57BL/6J mice, GW 4869 (1.25 mg/kg, i.p., q.d., 7 days prior and during behavioral testing for a total of 21 daily injections) impaired early phases of spatial reference memory, but did not decrease latency to locate the hidden platform with repeated training trials [2].

References:

[1]. Luberto C, Hassler D F, Signorelli P, et al. Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase. Journal of Biological Chemistry, 2002, 277(43): 41128-41139.

[2]. Tabatadze N, Savonenko A, Song H, et al. Inhibition of neutral sphingomyelinase-2 perturbs brain sphingolipid balance and spatial memory in mice. Journal of Neuroscience Research, 2010, 88(13): 2940-2951.