| CAS NO: | 53847-30-6 |
| 包装: | 1mg (solution) |
| 市场价: | 1890元 |
| Physical Appearance | A solution in acetonitrile. To change the solvent, simply evaporate the acetonitrile under a gentle stream of nitrogen and immediately add the solvent of choice. |
| Storage | Store at -80°C |
| M.Wt | 378.55 |
| Cas No. | 53847-30-6 |
| Formula | C23H38O4 |
| Solubility | Soluble in DMSO |
| Chemical Name | (5Z,8Z,11Z,14Z)-1,3-dihydroxypropan-2-yl icosa-5,8,11,14-tetraenoate |
| Canonical SMILES | CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(OC(CO)CO)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
2-Arachidonoyl glycerol is an endogenous agonist of the cannabinoid (CB) receptors CB1 and CB2 (Ki = 25.3 ~ 472 and 145 ~ 1400 nM, respectively) [1-3].
CB1 receptors are expressed mainly by neurons of the central and peripheral nervous system whilst CB2 receptors occur in certain non-neuronal tissues, particularly in immune cells, with both coupled to G proteins. CB receptors play important roles in the control of memory, cognition, movement and pain perception [1, 3].
In NG108-15 neuroblastoma × glioma hybrid cells, 2-arachidonoyl glycerol, at a concentration of 0.3 nM, induced a rapid, transient increase in intracellular free calcium through a CB1 receptor-dependent mechanism. 2-Arachidonoyl glycerol was the most potent compound examined, when compared with other potent CB receptor agonists including HU-210 and CP55940 [2].
In male Sprague-Dawley rats, 2-arachidonoyl glycerol (0.1 ~ 1.0 mg/kg, i.v.) preferentially stimulated nucleus accumbens (NAc) shell as compared to the NAc core. NAc shell dopamine increased by ~ 25% over basal value at the highest doses tested (0.5 and 1.0 mg/kg, i.v.) [4].
References:
[1]. Stella N, Schweitzer P, Piomelli D. A second endogenous cannabinoid that modulates long-term potentiation. Nature, 1997, 388(6644): 773-778.
[2]. Sugiura T, Kodaka T, Nakane S, et al. Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds. Journal of Biological Chemistry, 1999, 274(5): 2794-2801.
[3]. Pertwee R G. Pharmacology of cannabinoid receptor ligands. Current Medicinal Chemistry, 1999, 6(8): 635-664.
[4]. De Luca M A, Valentini V, Bimpisidis Z, et al. Endocannabinoid 2-arachidonoylglycerol self-administration by Sprague-Dawley rats and stimulation of in vivo dopamine transmission in the nucleus accumbens shell. Front Psychiatry, 2014, 5(140): 1-9.
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