| CAS NO: | 577-64-0 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| Physical Appearance | A white solid |
| Storage | Store at -20°C |
| M.Wt | 348.3 |
| Cas No. | 577-64-0 |
| Formula | C17H16O8 |
| Synonyms | Dimethylosoic Acid,RES-1214-1,TAN 1415A |
| Solubility | Soluble in ethanol;Soluble in DMSO;Soluble in dimethyl formamide |
| Chemical Name | 2-(2-carboxy-3-hydroxy-5-methylphenoxy)-5-hydroxy-3-methoxy-benzoic acid, 1-methyl ester |
| Canonical SMILES | CC1=CC(O)=C(C(O)=O)C(OC2=C(OC)C=C(O)C=C2C(OC)=O)=C1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
IC50: 10 μM for ET-1 binding to the ETA receptor ofA10 cells
Asterric Acid is an ETA receptor inhibitor.
Endothelin (ET), a potent vasoconstrictor/pressor peptide consisting of 21 amino acid residues, was first isolated from the cultures of porcine aortic endothelial cells. Analyses of a human genomic library reveals three forms of ET (ET-1, ET-2 and ET-3) with more than 70% homology with one another. In various organs, high affinity and specific receptors for ET have been found, which have been classfied as receptors ETA and ETB. ET-1 has potent and long-lasting vasoconstrictive activity, as a result of binding to the ETA receptor.
In vitro: Previous study asterric acid isolated as an active substance from the culture filtrate of a fungus, Aspergillus sp. Asterric acid had also been reported as a metabolite of a fungus. It was found that asterric acid had the property of inhibiting ET-1 binding to the ETA receptor of A10 cells, but it showed no inhibitory activity against ANP and A II binding at 10 mM, which indicated that asterric acid displayed as a specific inhibitor of ET-1 binding [1].
In vivo: Up to now, there is no animal in vivo data reported.
Clinical trial: So far, no clinical study has been conducted.
Reference:
[1] Ohashi, H. ,Akiyama, H.,Nishikori, K., et al. Asterric acid, a new endothelin binding inhibitor. Journal of Antibiotics 45, 1684-1685 (1992).
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