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Monazomycin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Monazomycin图片
CAS NO:11006-31-8
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍

化学性质

Physical AppearanceA solid
StorageStore at -20°C
M.Wt1364.8
Cas No.11006-31-8
FormulaC72H133NO22
SynonymsTakacidin,U-0142
SolubilitySoluble in DMSO
Chemical Name48-(7-amino-1-methylheptyl)-8,10,16,20,24,26,28,32,36,38,40,42,44,46-tetradecahydroxy-23-(α-D-mannopyranosyloxy)-9,15,17,19,21,25,31,33,39,41,47-undecamethyl-oxacyclooctatetraconta-13,17,21,29-tetraen-2-one
Canonical SMILESOC(CC(C(C(C(O[C@@H]1[C@@H](O)[C@@H](O)[C@H](O)C(CO)O1)/C=C(C)/C(O)C(C)/C=C(C)/C(O)C(C)/C=C/CCC(O)C(C)C(O)CCCCCC2=O)O)C)O)/C=C/C(C)C(O)C(C)CCC(O)CC(O)C(C)C(O)C(C)C(O)CC(O)CC(O)C(C)C(O2)C(C)CCCCCCN
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Monazomycin is a positively charged and polyenelike antibiotic produced by Streptomyces [1].

Monazomycin is able to induce a voltage-dependent conductance in lipid bilayer membranes. Monazomycin is selective for monovalent cations and can alter the membrane conductance when applied to one or both sides of the membrane [1]. Application of micromolar amounts of monazomycin on one side of phospholipid bilayer membranes induced dramatic voltage-dependent conductance effects. The steady-state conductance was proportional to the 5th power of the monazomycin concentration and increased exponentially with positive voltage (monazomycin side positive); there was an e-fold change in conductance per 4–6 mv. The major current-carrying ions were univalent cations. Monazomycin monomers cooperated to form a multimolecular conductance channel. The voltage control of conductance arose from the electric field driving monazomycin molecules at the membrane surface into the membrane and thus affecting the number of channels that were formed [2].

References:
[1] Bamberg E, Janko K.  Single channel conductance at lipid bilayer membranes in presence of monazomycin[J]. Biochimica et Biophysica Acta (BBA)-Biomembranes, 1976, 426(3): 447-450.
[2] Muller R U, Finkelstein A.  Voltage-dependent conductance induced in thin lipid membranes by monazomycin[J]. The Journal of general physiology, 1972, 60(3): 263-284.