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BW A868C
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BW A868C图片
CAS NO:118675-50-6
包装与价格:
包装价格(元)
1mg (solution)电议
5mg (solution)电议
10mg (solution)电议

产品介绍

化学性质

Physical AppearanceA solution in ethanol. To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
StorageStore at -20°C
M.Wt459.6
Cas No.118675-50-6
FormulaC25H37N3O5
Solubility≤20mg/ml in DMSO;20mg/ml in dimethyl formamide
Chemical Name3-[(2-cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-1-(phenylmethyl)-4-imidazolidineheptanoic acid
Canonical SMILESO=C1C(CCCCCCC(O)=O)N(NCC(O)C2CCCCC2)C(N1CC3=CC=CC=C3)=O
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

资料参考

BW A868C is a novel, selective and potent competitive antagonist of prostaglandin D2 (PGD2) [1].

Prostaglandin D2 has been widely distributed in rat brain, spinal cord and pituitary and may act as a neuromodulator in the central nervous system [2]. Prostaglandin D2 is critical for the development of allergic diseases such as asthma.

In vitro: In glycerol-lysed human platelets, BW245C activated adenylate cyclase in a biphasic manner. BW A868C showed no effect on carbacyclin, iloprost, prostacyclin, PGE1 and PGE2 at a concentration 1,000 fold that of its KB against PGD2 and BW245C [1]. BW A868C showed no effect on human TP, IP, EP1, EP2, and FP receptors. The Ki value for BW A868C is approximately 1.7 nM[1] .In isolated rings of rabbit saphenous vein (RbSV) pre-contracted with 40 mM KCl, BW245C caused concentration-dependent relaxations with an EC50 of 38 nM [3].

References:
[1] Giles H, Leff P, Bolofo M L, et al.  The classification of prostaglandin DP‐ eceptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonist[J]. British journal of pharmacology, 1989, 96(2): 291-300.
[2] Shimizu T, Mizuno N, Amano T, et al.  Prostaglandin D2, a neuromodulator[J]. Proceedings of the National Academy of Sciences, 1979, 76(12): 6231-6234.
[3] Lydford S J, McKechnie K C W, Leff P.  Interaction of BW A868C, a prostanoid DP-receptor antagonist, with two receptor subtypes in the rabbit isolated saphenous vein[J]. Prostaglandins, 1996, 52(2): 125-139.