Spinosyn A

立即咨询

Spinosyn A

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

131929-60-7

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议

产品介绍

化学性质

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	732
Cas No.	131929-60-7
Formula	C₄₁H₆₅NO₁₀
Synonyms	A-83543A\|Lepicidin A
Solubility	Soluble in DMSO
Chemical Name	(2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)-2-[(6-deoxy-2,3,4-tri-O-methyl-α-L-mannopyranosyl)oxy]-13-[[(2R,5S,6R)-5-(dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-9-ethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-14-methyl-1H-as-indaceno[3,
Canonical SMILES	CN(C)[C@H]1CC[C@@](O[C@H]([C@@H](C)C2=O)CCC[C@H](CC)OC(C[C@]3([H])C2=C[C@]4([H])[C@@]3([H])C=C[C@@]5([H])[C@@]4([H])C[C@H](O[C@]6([H])O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]6OC)C5)=O)([H])O[C@@H]1C
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Spinosyn A is an insect nicotinic acetylcholinesterase receptors (nAChRs) agonist and potent insecticide.

The spinosyns are a family of macrolide natural products produced by the soil microorganism Saccharopolyspora spinosa. Spinosyn A is identified as a naturally-occurring macrocyclic lactone that is a potent insecticide.

In vitro: The mixture of spinosyns A and D, a commercial insecticide TracerTM (DowAgroSciences), is useful against various crop pests such as tobacco budworm. It was found that the deoxy analogs of spinosyns A were more potent insecticides than their respective parent factor. Moreover, the 2’-desmethoxy analogs of spinosyns A showed insecticidal potency against H. virescens greater than that of spinosyns A and D, suggesting that polarity was not well tolerated. Furthermore, the activity of 3'-deoxy spinosyn J was about the same as spinosyn A, and the activity of 2'-deoxy spinosyn H was found to be slightly greater than that of spinosyn A [1].

In vivo: Currently, there is no animal in vivo data reported.

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] L. C. Creemer, H. A. Kirst, J. W. Paschal, et al. Synthesis and insecticidal activity of spinosyn analogs functionally altered at the 2'-,3'- and 4'-positions of the rhamnose moiety. J.Antibiot.(Tokyo) 53(2), 171-178 (2000).