| 包装: | 25 units |
| 市场价: | 4690元 |
| Gene ID: | 835 | Accession #: | P42575 |
| Alternate Names: | Active Human Caspase-2, Active Caspase-2, Caspase-2 Enzyme, Recombinant caspase-2, human caspase-2, human caspases, active caspases. | ||
| Source: | Escherichia Coli. | M.Wt: | two large (19 kDa) and two small (12 kDa) subunits |
| Appearance: | Lyophilized powder | Storage: | Store at -70℃ |
| Formulation: | Lyophilized powder | ||
| Solubility: | Reconstitute to 1 unit per μl in PBS containing 15% glycerol. | ||
| Shipping Condition: | gel pack. | Handling: | Centrifuge the vial prior to opening. |
| Usage: | For Research Use Only! Not to be used in humans. | ||
Caspase-2 (also know as Ich-1, Nedd-2) is a member of the caspase-family of cysteine proteases. Caspase-2 exists in cells as an inactive proenzyme. During apoptosis, pro-caspase-2 is processed at aspartate residues by self-proteolysis and/or cleavage by upstream caspases. The active caspase-2 is a heterotetramer consisting of two large (19 kDa) and two small (12 kDa) subunits.
The recombinant active human caspase-2 is expressed in E. coli. The active caspase-2 preferentially cleaves caspase-2 substrates (VDVAD-AFC or VDVAD-pNA) and is routinely tested for its ability to enzymatically cleave Ac-VDVAD-pNA or Ac-VDVAD-AFC.
Active caspase-2 is useful in studying enzyme regulation, determining target substrates, screening caspase inhibitors, or as a positive control in caspase activity assays. Recommend using 1 unit/assay for analyzing caspase activity.
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