描述
| Gene ID: | 3952 | Accession #: | P41159 |
| Alternate Names: | OB Protein, Obesity Protein, OBS, Obesity factor, HuB219, OB receptor, CD_antigen=CD295 |
| Source: | Human | M.Wt: | 95.0 kDa (predicted) 130-140 kDa on a gel |
| Appearance: | Lyophilized protein | Storage: | Store at -70℃ |
| Formulation: | Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. |
| Solubility: | The lyophilized Leptin Binding Domain is very soluble in H2O and most aqueous buffers below and above the isoelectric point (~ 5.9). |
| Shipping Condition: | Blue Ice. | Handling: | Centrifuge the vial prior to opening. |
| Usage: | For Research Use Only! Not to be used in humans. |
资料参考
Leptin receptor is also called LEP-R or OB-R. It is a human protein that is encoded by the Lepr gene. Interaction of Leptin and Leptin receptor is important for bodyweight and bone mass regulation in mammals through hypothalamic effects on satiety and energy expenditure. Numerous studies broadly show that Lepr gene polymorphism is related to the levels of blood glucose, insulin, leptin and triglyceride. Deficiency of Lepr gene can directly lead to obesity.
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