NBQX disodium salt

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NBQX disodium salt

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

479347-86-9

包装与价格：

包装	价格(元)
10mg	电议
50mg	电议

产品介绍

化学性质

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	380.24
Cas No.	479347-86-9
Formula	C₁₂H₆N₄O₆SNa₂
Solubility	Soluble in H2O
Chemical Name	sodium 6-nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-bis(olate)
Canonical SMILES	O=S(N)(C1=CC=CC2=C1C([N+]([O-])=O)=CC(N=C3[O-])=C2N=C3[O-])=O.[Na+].[Na+]
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

NBQX disodium salt is a potent, highly selective and competitive antagonist of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors (AMPARs). The AMPAR is one type of ionotropic glutamate receptors, well known to be involved in various neurological disorders such as Alzheimer disease, schizophrenia, and epilepsy, by mediating long-term potentiation, excitotoxicity, or both. Inhibition of AMPARs with NBQX shows neuroprotective and anticonvulsant activity.

References:

1. Fukushima K, Tabata Y, Imaizumi Y, et al. Characterization of human hippocampal neural stem/progenitor cells and their application to physiologically relevant assays for multiple ionotropic glutamate receptors. Journal of Biomolecular Screening, 2014, 19(8): 1174-1184.

2. Chen W, Li YS, Gao J, et al. AMPA Receptor Antagonist NBQX Decreased Seizures by Normalization of Perineuronal Nets. PLoS One, 2016, 11(11): e0166672.

试验操作

Cell experiment:[1]
Cell lines	HIP-009 cells
Reaction Conditions	1 h incubation
Applications	NBQX inhibited both AMPA or kainic acid (KA) induced signals in a concentration-dependent manner, with IC50 values being 0.7 ± 0.1 and 0.7 ± 0.03 μM, respectively. The AMPA-evoked calcium rise was completely inhibited by NBQX, whereas 68.6% ± 1.3% inhibition of the KA-induced signal was observed with 30 μM of NBQX treatment.
Animal experiment:[2]
Animal models	Male Wistar rats intraperitoneally injected with pentylenetetrazole
Dosage form	20 mg/kg Once daily by intraperitoneal injection for 3 days
Applications	NBQX was sufficient to decrease pentylenetetrazole-induced seizures through increasing the latency to seizures, decrease the duration of seizure onset, and reduce the scores for the severity of seizures.
Note	The technical data provided above is for reference only.
	References: 1. Fukushima K, Tabata Y, Imaizumi Y, et al. Characterization of human hippocampal neural stem/progenitor cells and their application to physiologically relevant assays for multiple ionotropic glutamate receptors. Journal of Biomolecular Screening, 2014, 19(8): 1174-1184. 2. Chen W, Li YS, Gao J, et al. AMPA Receptor Antagonist NBQX Decreased Seizures by Normalization of Perineuronal Nets. PLoS One, 2016, 11(11): e0166672.