CU CPT 4a

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CU CPT 4a

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1279713-77-7

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议

产品介绍

化学性质

Physical Appearance	White solid
Storage	Store at 4°C
M.Wt	377.82
Cas No.	1279713-77-7
Formula	C₁₈H₁₃ClFNO₃S
Solubility	<37.78mg/ml in DMSO
Chemical Name	(R,Z)-2-(((3-chloro-6-fluorobenzo[b]thiophen-2-yl)(hydroxy)methylene)amino)-3-phenylpropanoic acid
Canonical SMILES	ClC(C1=C(S2)C=C(F)C=C1)=C2/C(O)=N/[C@](C(O)=O)([H])CC3=CC=CC=C3
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

CU CPT 4a is a selective TLR3 inhibitor with IC50 of 3.44 μM in RAW 264.7 cells. It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the production of TNF-α and IL-1β in whole cells. It reduces the mortality of crypt cells in mice and reduces gastrointestinal syndrome.

References:

[1]. Cheng K, Wang X, Yin H. Small-Molecule Inhibitors of the TLR3/dsRNA Complex. Journal of the American Chemical Society, 2011, 133(11): 3764-3767.

[2]. Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome. Nature Communications, 2014, 5.