STF 31

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STF 31

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

724741-75-7

包装与价格：

包装	价格(元)
10mg	电议
50mg	电议

产品介绍

化学性质

Physical Appearance	A solid
Storage	Store at RT
M.Wt	423.53
Cas No.	724741-75-7
Formula	C₂₃H₂₅N₃O₃S
Solubility	≥42.4 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
Chemical Name	4-((4-(tert-butyl)phenylsulfonamido)methyl)-N-(pyridin-3-yl)benzamide
Canonical SMILES	O=S(NCC1=CC=C(C(NC2=CC=CN=C2)=O)C=C1)(C3=CC=C(C=C3)C(C)(C)C)=O
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

STF-31 is a selective inhibitor of glucose transporter 1 (GLUT1), with an IC50 of 1 μΜ [1].

The inactivated von Hippel-Lindau (VHL) tumor suppressor gene drives renal cell carcinomas (RCCs) development, which imparts the reliance on the GLUT1 and aerobic glycolysis. Compounds of the 3-series, exemplified by STF-31, selectively kills RCCs by specifically targeting glucose uptake through GLU1, on which is the unique dependence of these cells for survival.

STF-31 (0.01-10 μΜ; 10 days) is specifically toxic to RCC4 cells without VHL, while wild-type RCC4 cells (RCC4/VHL) are relatively unaffected. Wild-type RCC4 cells treated with STF-31 (5 μΜ; 10 days) largely recovery, while RCC4 cells dose not on the same condition. No evidence proved the drug-induced cells autophagy, apoptosis, or DNA damages, but wild-type RCC4 cells underwent necrotic cell death in response to STF-31 by the ability of the cells to exclude trypan blue [1].

Soluble analog of STF-31 (11.6 mg/kg; i.p.) treatment delayed tumor growth in mice with VHL-deficient RCC tumor xenografts [1]. STF-31 (10 mg/kg; i.p.; twice daily for 2 days, followed by once daily for another 3 days) did not affect normal mice body weight, behavior and Scotopic electroretinography (ERG) responses. STF-31 reduced light-induced CX3CR1gfp/+ mice microglial activation and retinal degeneration [2].

Reference:

[1] Chan D A, Sutphin P D, Nguyen P, et al. Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Sci Transl Med. 2011, 3(94): 94ra70.

[2] Wang L X, Pavlou S, Du X, et al. Glucose transporter 1 critically controls microglial activation through facilitating glycolysis. Mol Neurodegener. 2019, 14(1): 2.