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Kevetrin hydrochloride(4-Isothioureidobutyronitrile hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Kevetrin hydrochloride(4-Isothioureidobutyronitrile hydrochloride)图片
CAS NO:66592-89-0
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
10mg电议
50mg电议
100mg电议
500mg电议

产品介绍
Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride) 是 p53 的有效激活剂,可诱导 TP53 野生型和突变型急性髓细胞白血病细胞凋亡。 Kevetrin 对胚细胞具有优先的细胞毒活性。
Cas No.66592-89-0
别名4-Isothioureidobutyronitrile hydrochloride; thioureidobutyronitrile hydrochloride; thioureido butyronitrile hydrochloride
Canonical SMILESNC(SCCCC#N)=N.[H]Cl
分子式C5H10ClN3S
分子量179.67
溶解度DMSO : ≥ 40 mg/mL (222.63 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Target:p53in vitro: Kevetrin activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell apoptosis. Kevetrin may be effective in drug-resistant cancers with mutated p53. p53 tumor suppressor, a transcription factor regulating the expression of many stress response genes and mediating various anti-proliferative processes, is often mutated in cancer cells. in vivo: Kevetrin has demonstrated potent anti-tumor efficacy against various carcinoma xenograft models: lung, breast, colon, prostate and squamous cell carcinoma, and in a leukemia tumor model. In drug-resistant cell lines, Kevetrin has shown excellent activity, galvanizing the Company to focus on Kevetrin's development potential in this area.