Gemfibrozil 1-O-β-Glucuronide 是 Gemfibrozil 的一种代谢物，是一种有效且具有竞争力的 P450 (CYP) 同工型 CYP2C8 抑制剂，IC50 为 4.07 μM.
| Cas No. | 91683-38-4 |
| 别名 | 吉非罗齐酰基β-D-葡萄糖醛酸 |
| Canonical SMILES | CC1=CC=C(C)C(OCCCC(C)(C)C(O[C@@H]2O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]2O)=O)=C1 |
| 分子式 | C21H30O9 |
| 分子量 | 426.5 |
| 溶解度 | Methanol: Slightly Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Gemfibrozil 1-O-β-glucuronide is a major metabolite of gemfibrozil that is formed when gemfibrozil undergoes glucuronidation by UDP-glucuronosyltransferase (UGT) 2B7. Gemfibrozil 1-O-β-glucuronide is an inhibitor of the cytochrome P450 (CYP) isoform CYP2C8 (IC50 = 4.1 µM). It is taken up by organic anion transporting polypeptide 1B1 (OATP1B1) in sandwich cultured human hepatocytes (SCHHs) and inhibits cellular uptake of valsartan in MDCK cells expressing OATP1B1 (IC50 = 20.4 µM). |
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