Folipastatin 是一种有效的磷脂酶 A2 抑制剂，IC50 为 39 μM。
| Cas No. | 139959-71-0 |
| 别名 | 磷脂他汀 |
| Canonical SMILES | CC1=C2C(OC(C(C)=C(O)C=C3/C(C)=C/C)=C3C(O2)=O)=C(/C(C)=C\C)C=C1O |
| 分子式 | C23H24O5 |
| 分子量 | 380.4 |
| 溶解度 | DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Folipastatin is a fungal metabolite produced by A. unguis and an inhibitor of phospholipase A2 (PLA2; IC50 = 39 μM). It inhibits release of arachidonic acid from rat polymorphonuclear leukocytes (IC50 = 24 μM). Folipistatin also inhibits radioligand binding to L-type calcium channels in porcine heart membranes (IC50 = 0.39 μM) but has no effect on contraction of taenia (IC50 = >100 μM). |
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