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Furagin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Furagin图片
CAS NO:1672-88-4
包装与价格:
包装价格(元)
Free Sample (0.1-0.5mg)电议
10mM (in 1mL DMSO)电议
1g电议
5g电议
10g电议
50g电议

产品介绍
Furagin是nitrofurantoin的类似物,有抗菌活性。
Cas No.1672-88-4
别名呋喃烯啶; Furazidine; Furazidin
Canonical SMILESO=C1NC(CN1/N=C/C=C/C2=CC=C(O2)[N+]([O-])=O)=O
分子式C10H8N4O5
分子量264.19
溶解度DMSO: ≥ 33 mg/mL (124.91 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Furagin, nitrofurantoin analog, is an anti-bacterial agent. Furagin is 2-substituted 5-nitrofuran, chemically and structurally similar to well-known antibacterial compound nitrofurantoin.IC50 Value: Target: Antibacterialin vitro: The furagin concentrations in serum remain several hours above the MIC concentrations of many pathogenic bacteria. Despite the high concentrations in serum, the urine levels of furagin were generally lower than those of nitrofurantoin. The 24 hr recoveries in urine were 8--13% for furagin and about 36% for nitrofurantoin [1].in vivo: A time-independent increase in SCE frequency was found in lymphocytes of children treated with furagin. Total CA frequency did not differ significantly between groups of children with various duration of furagin treatment [2]. Women were randomised into two groups receiving either ciprofloxacin 250mg twice a day for 3 days (n=13) or furagin 100mg three times a day for 7 days (n=14). Median lengths of follow-up were 4 days and 5 days in the ciprofloxacin and furagin groups, respectively [3].

[1]. Mannisto P, et al. Pharmacokinetics of furagin, a new nitrofurantoin congener, on human volunteers. Int J Clin Pharmacol Biopharm. 1979 Jun;17(6):264-70. [2]. Slapsyte G, et al. Cytogenetic analysis of children under long-term antibacterial therapy with nitroheterocyclic compound furagin. Mutat Res. 2001 Apr 5;491(1-2):25-30. [3]. Dybowski B, et al. Ciprofloxacin and furagin in acute cystitis: comparison of early immune and microbiological results. Int J Antimicrob Agents. 2008 Feb;31(2):130-4.