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GW 766994(GW 994)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
GW 766994(GW 994)图片
CAS NO:408303-43-5
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
GW 766994 (GW 994) (GW 994) 是一种具有口服活性的特异性趋化因子受体 3 (CCR3) 拮抗剂。
Cas No.408303-43-5
别名GW 994
Canonical SMILESNC(C(C=C1)=CC=C1CNC(NC[C@H](OCC2)CN2CC3=CC(Cl)=C(Cl)C=C3)=O)=O
分子式C21H24Cl2N4O3
分子量451.35
溶解度DMSO : 56 mg/mL (124.07 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist, which has entered clinical trial for asthma and eosinophilic bronchitis.

GW 766994 is a specific chemokine receptor-3 (CCR3) antagonist, which has entered clinical trial for asthma and eosinophilic bronchitis[1]. GW 766994 (10 μM) reverses CCL11-induced activation of CDK5, phosphorylations of CDK5, GSK3β, and increased phosphorylation of tau in hippocampal neurons[2].

[1]. Neighbour H, et al. Safety and efficacy of an oral CCR3 antagonist in patients with asthma and eosinophilic bronchitis: a randomized, placebo-controlled clinical trial. Clin Exp Allergy. 2014 Apr;44(4):508-16. [2]. Zhu C, et al. Targeting CCR3 to Reduce Amyloid-β Production, Tau Hyperphosphorylation, and Synaptic Loss in a Mouse Model of Alzheimer's Disease. Mol Neurobiol. 2017 Dec;54(10):7964-7978.