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L 888607 Racemate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
L 888607 Racemate图片
CAS NO:1030017-51-6
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
L888607Racemate是选择性前列腺素D2受体亚型1(DP1)的拮抗剂,其对DP1和TP的Ki值分别为132nM和17nM。
Cas No.1030017-51-6
Canonical SMILESO=C(O)CC1CCN2C1=C(SC3=CC=C(Cl)C=C3)C4=C2C=C(F)C=C4
分子式C19H15ClFNO2S
分子量375.84
溶解度DMSO : 6 mg/mL (15.96 mM);Water :< 0.1 mg/mL (insoluble)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

L 888607 Racemate is a selective prostaglandin D2 receptor subtype 1 (DP1) antagonist, with Kis of 132 nM and 17 nM for DP1 and thromboxane A2 receptor (TP), respectively.

L 888607 Racemate (compound 3) maintains a modest binding affinity for the DP1 receptor (Ki = 132 nM) and is actually 8-fold more potent on the TP receptor (Ki = 17 nM)[1].

[1]. Beaulieu C, et al. Identification of prostaglandin D2 receptor antagonists based on a tetrahydropyridoindole scaffold. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2696-700.