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PBI-4050 sodium salt(Setogepram(sodium salt))
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
PBI-4050 sodium salt(Setogepram(sodium salt))图片
CAS NO:1254472-97-3
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
Fezagepras (Setogepram) sodium 作为 GPR40 的口服活性激动剂和 GPR84 的拮抗剂或反向激动剂。
Cas No.1254472-97-3
别名Setogepram sodium; PBI-4050 sodium
Canonical SMILESO=C(O[Na])CC1=CC(CCCCC)=CC=C1
分子式C13H17NaO2
分子量228.26
溶解度Water : ≥ 100 mg/mL (438.10 mM);DMSO : ≥ 64 mg/mL (280.38 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PBI-4050 acts as an agonist for GPR40 and as an antagonist or inverse agonist for GPR84.

PBI-4050, a synthetic analogue of a medium-chain length fatty acid, binds to FFA receptor 1 (FFAR1/GPR40) and GPR84. To determine the potential role of PBI-4050 on diabetic kidney disease, The accelerated model of type 2 diabetic nephropathy, eNOS-/- db/db mice are utilized. Mice are treated with either vehicle or PBI-4050 (100 mg/kg) by daily gavage from 8-20 weeks of age. eNOS-/- db/db mice are moderately hypertensive, and PBI-4050 has no effect on blood pressure. Furthermore, compared with vehicle-treated mice, which exhibit a decrease in glomerular filtration rate (GFR) from 8-20 weeks, PBI-4050 preserves GFR. Podocyte number per glomerulus section markedly decreases from 8-20 weeks of age in vehicle-treated mice, while PBI-4050 treatment significantly slows this loss[1].

[1]. Li Y, et al. Fatty acid receptor modulator PBI-4050 inhibits kidney fibrosis and improves glycemic control. JCI Insight. 2018 May 17;3(10). pii: 120365.