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Gossypin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Gossypin图片
CAS NO:652-78-8
包装与价格：
包装价格(元)
5mg电议
10mg电议

产品介绍
Gossypin是从Hibiscusvitifolius中分离得到的一种黄酮，具有抗氧化、抗炎、抗癌、抗衰老、抗糖尿病、镇痛和保护肝脏的活性。Gossypin抑制NF-κB和NF-κB的调节基因表达。在小鼠原代骨髓细胞和RAW264.7细胞中，Gossypin也可抑制RANKL诱导的破骨细胞形成。
Cas No.652-78-8
别名棉纤维素
Canonical SMILESO=C1C(O)=C(C2=CC=C(O)C(O)=C2)OC3=C(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)C(O)=CC(O)=C13
分子式C21H20O13
分子量480.38
溶解度30 mg/ml in DMF,PBS (pH 7.2) (1:2): 0.3 mg/ml in DMF,25 mg/ml in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Gossypin is a flavone isolated from Hibiscus vitifolius and has antioxidant, antiinflammatory, anticancer, anticataract, antidiabetic, analgesic and hepatoprotective activities. Gossypin inhibits NF-κB and NF-κB-regulated gene expression. Gossypin inhibits RANKL-induced osteoclastogenesis both in mouse primary bone marrow cells and RAW 264.7 cells in vitro[1][2].

[1]. Ajaikumar B Kunnumakkara, et al. Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis. Blood. 2007 Jun 15;109(12):5112-21. [2]. Kanika Patel, et al. Gossypin: A phytochemical of multispectrum potential. the Journal of Coastal Life Medicine.