CAS NO: | 2092921-50-9 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
Cas No. | 2092921-50-9 |
Canonical SMILES | COC1=C(OCCCCC2=CC(N)=NC=C2)C=CC(NC(NCCCN3C(C)=CN=C3)=S)=C1 |
分子式 | C24H32N6O2S |
分子量 | 468.61 |
溶解度 | Soluble in DMSO |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Glutaminyl Cyclase Inhibitor 3 (compound 212 ), a designed anti-Alzheimer's compound, is a potent human Glutaminyl Cyclase (GC) inhibitor, with an IC50 of 4.5 nM. Glutaminyl Cyclase-IN-1 (compound 212) significantly reduced the brain concentrations of pyroform Aβ and total Aβ and restored cognitive functions[1]. IC50: 4.5 nM (hGC)[1]. [1]. Hoang VH, et al. Discovery of Potent Human Glutaminyl Cyclase Inhibitors as Anti-Alzheimer's Agents Based on Rational Design. J Med Chem. 2017 Mar 23;60(6):2573-2590. |