您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Glutaminyl Cyclase Inhibitor 3
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Glutaminyl Cyclase Inhibitor 3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Glutaminyl Cyclase Inhibitor 3图片
CAS NO:2092921-50-9
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Glutaminyl Cyclase Inhibitor 3 (compound 212 ) 是一种具有抗阿尔兹海默症作用的化合物,是有效的人谷氨酰胺酰环化酶 (GC) 的抑制剂,其 IC50 值为 4.5 nM。Glutaminyl Cyclase-IN-1 (compound 212) 可显著降低大脑Aβ的浓度,并恢复认知功能。
Cas No.2092921-50-9
Canonical SMILESCOC1=C(OCCCCC2=CC(N)=NC=C2)C=CC(NC(NCCCN3C(C)=CN=C3)=S)=C1
分子式C24H32N6O2S
分子量468.61
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Glutaminyl Cyclase Inhibitor 3 (compound 212 ), a designed anti-Alzheimer's compound, is a potent human Glutaminyl Cyclase (GC) inhibitor, with an IC50 of 4.5 nM. Glutaminyl Cyclase-IN-1 (compound 212) significantly reduced the brain concentrations of pyroform Aβ and total Aβ and restored cognitive functions[1]. IC50: 4.5 nM (hGC)[1].

[1]. Hoang VH, et al. Discovery of Potent Human Glutaminyl Cyclase Inhibitors as Anti-Alzheimer's Agents Based on Rational Design. J Med Chem. 2017 Mar 23;60(6):2573-2590.