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Galanthaminone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Galanthaminone图片
CAS NO:510-77-0
包装与价格:
包装价格(元)
Free Sample (0.1-0.5mg)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Galanthaminone是竞争性可逆的胆碱酯酶(AChE)抑制剂,可作用于多种记忆障碍疾病。
Cas No.510-77-0
别名氢溴酸加兰他敏,(-)-Narwedine; Narwedin
Canonical SMILESO=C1C=C[C@@]23CCN(C)CC4=CC=C(OC)C(O[C@@]3([H])C1)=C24
分子式C17H19NO3
分子量285.34
溶解度DMSO: 10 mg/mL (35.05 mM); Water:< 0.1 mg/mL (insoluble)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments. AChE

Galanthaminone reduces the action of AChE and therefore tends to increase the concentration of acetylcholine in the brain. is also an allosteric ligand at nicotinic acetylcholine receptors. It has shown activity in modulating the nicotinic cholinergic receptors on cholinergic neurons to increase acetylcholine release.

Absorption of Galanthaminone is rapid and complete and shows linear pharmacokinetics. It is well absorbed with absolute oral bioavailability between 80 and 100%. It has a half-life of seven hours. Peak effect of inhibiting acetylcholinesterase was achieved about one hour after a single oral dose of 8 mg in some healthy volunteers.

[1]. Greenblatt HM, et al. Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A resolution. FEBS Lett. 1999 Dec 17;463(3):321-6. [2]. Heinrich M, et al. Galanthamine from snowdrop--the development of a modern drug against Alzheimer's disease from local Caucasian knowledge. J Ethnopharmacol. 2004 Jun;92(2-3):147-62.