SR 59230A hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1135278-41-9

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议

产品介绍

化学性质

Physical Appearance	White solid
Storage	Store at RT
M.Wt	361.91
Cas No.	1135278-41-9
Formula	C₂₁H₂₇NO₂·HCl
Solubility	Soluble in DMSO
Chemical Name	(S)-1-(2-ethylphenoxy)-3-(((S)-1,2,3,4-tetrahydronaphthalen-1-yl)amino)propan-2-ol hydrochloride
Canonical SMILES	O[C@H](COC1=CC=CC=C1CC)CN[C@H]2CCCC3=CC=CC=C23.Cl
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

R 59230A hydrochloride is a selective and potent antagonist of β₃adrenoceptor, with IC50 values being 40, 408, and 648 nM for β₃, β₁, and β₂adrenergic receptors, respectively. β₃adrenoceptor, predominately located in adipose tissue, is mainly responsible for the regulation of lipolysis and thermogenesis. In addition, β₃adrenoceptor has also been found to be involved in different tumor conditions, such as neuroblastoma, via the regulation of the bioactive lipid sphingosine 1-phosphate metabolism and signaling.

References:

1. Nisoli E, Tonello C, Landi M, et al. Functional studies of the first selective beta 3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes. Molecular Pharmacology, 1996, 49(1): 7-14.

2. Kanzler SA, Januario AC, Paschoalini MA. Involvement of β₃-adrenergic receptors in the control of food intake in rats. Brazilian Journal of Medical and Biological Research, 2011, 44(11): 1141-1147.

3. Bruno G, Cencetti F, Pini A, et al._β3-adrenoreceptor blockade reduces tumor growth and increases neuronal differentiation in neuroblastoma via SK2/S1P2 modulation. Oncogene, 2020, 39(2): 368-384.

4. Bexis S, Docherty JR. Role of α₁- and β₃-adrenoceptors in the modulation by SR59230A of the effects of MDMA on body temperature in the mouse. British Journal of Pharmacology, 2009, 158(1): 259-266.

试验操作

Cell experiment:[3]
Cell lines	Neuroblastoma cell lines, including murine Neuro-2A, as well as human BE(2)C and SK-N-BE(2)
Reaction Conditions	100 nM ~ 50 μM SR 59230A hydrochloride for 24 h incubation
Applications	SR 59230A hydrochloride was able to reduce cell viability in a dose-dependent manner in Neuro-2A, BE(2)C and SK-N-BE(2) neuroblastoma cell lines.
Animal experiment:[4]
Animal models	Male C-57BL6J wild-type mice, 22-35 g
Dosage form	0.5 or 5 mg/kg Injected subcutaneously 30 min prior to the subcutaneous injection of MDMA
Applications	At a low concentration of 0.5 mg/kg, SR 59230A hydrochloride produced a small but significant attenuation of the slowly developing hyperthermia to methylenedioxymethamphetamine (MDMA). At a high concentration of 5 mg/kg, SR 59230A hydrochloride revealed a significant and marked early hypothermic reaction to MDMA.
Note	The technical data provided above is for reference only.
	References: 1. Nisoli E, Tonello C, Landi M, et al. Functional studies of the first selective beta 3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes. Molecular Pharmacology, 1996, 49(1): 7-14. 2. Kanzler SA, Januario AC, Paschoalini MA. Involvement of β3-adrenergic receptors in the control of food intake in rats. Brazilian Journal of Medical and Biological Research, 2011, 44(11): 1141-1147. 3. Bruno G, Cencetti F, Pini A, et al. β3-adrenoreceptor blockade reduces tumor growth and increases neuronal differentiation in neuroblastoma via SK2/S1P2 modulation. Oncogene, 2020, 39(2): 368-384. 4. Bexis S, Docherty JR. Role of α1- and β3-adrenoceptors in the modulation by SR59230A of the effects of MDMA on body temperature in the mouse. British Journal of Pharmacology, 2009, 158(1): 259-266.