| CAS NO: | 112825-05-5 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 5mg | 电议 |
| 25mg | 电议 |
| Physical Appearance | White solid |
| Storage | Desiccate at -20°C |
| M.Wt | 874.93 |
| Cas No. | 112825-05-5 |
| Formula | C37H50N2O10·C6H8O7 |
| Solubility | Soluble in DMSO |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Methyllycaconitine citrate(MLA) is an antagonist of α7-containing neuronal nicotinic acetylcholine receptors (nAChRs; Ki = 1.4 nM)[1,2].
MLA inhibits the decreased cell viability induced by Aβ25-35, pretreatment with 5 and 10 μM. Aβ25-35treatment increases LC3-II levels, which is inhibited by administration of Methyllycaconitine citrate. MLA also inhibits Aβ-induced autophagosome accumulation in SH-SY5Y cells[3].
MLA inhibits methamphetamine(METH)-induced climbing behavior by 50%. MLA prevents a decrease in striatal synaptosome dopamine (DA) uptake, MLA significantly attenuates METH-induced neurotoxicity at 72 h post-treatment. MLA fully prevents microglial activation at 24 h post-treatment and tending to confirm its neuroprotective activity[4].
References：
[1]. Kalappa B I, Sun F, Johnson S R, et al. A positive allosteric modulator of α7 nAChRs augments neuroprotective effects of endogenous nicotinic agonists in cerebral ischaemia. Brit.J.Pharmacol, 2013, 169(8): 1862-1878.
[2]. Ward J M, Cockcroft V B, Lunt G G, et al. Methyllycaconitine: A selective probe for neuronal α-bungarotoxin binding sites. FEBS Lett, 1990, 270(1-2): 45-48 .
[3]. Zheng X, et al. Methyllycaconitine alleviates amyloid-β peptides-induced cytotoxicity in SH-SY5Y cells. PLoS One, 2014, 9(10): e111536.
[4]. Escubedo E, et al. Methyllycaconitine prevents methamphetamine-induced effects in mouse striatum: involvement of alpha7 nicotinic receptors. J Pharmacol Exp Ther, 2005, 315(2): 658-67.
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