您好，欢迎来到化工原料网！ [登录] [免费注册]
化工原料网
发布求购
位置：首页 > 产品库 > BuChE-IN-TM-10
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
BuChE-IN-TM-10
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
BuChE-IN-TM-10图片
CAS NO:2313524-95-5
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
BuChE-IN-TM-10 (TM-10)是一种有效的丁基胆碱酯酶 (BuChE) 抑制剂，其IC50 值为8.9 nM。BuChE inhibitor 1能够抑制和分解自诱导的Aβ聚合, 表现出强大的抗氧化活性和良好的血脑屏障 (BBB) 渗透性。有治疗阿尔兹海默症的潜能。
Cas No.2313524-95-5
别名TM-10
Canonical SMILESO=C(N1CC2=C(C=CC=C2)CC1)/C=C/C3=CC=C(OCCCCN(CC4=CC=CC=C4)CC)C(OC)=C3
分子式C32H38N2O3
分子量498.66
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

BuChE-IN-TM-10 (TM-10) is a potent butyrylcholinesterase (BuChE) inhibitor, with an IC50 of 8.9 nM. BuChE inhibitor 1 inhibits and disaggregates self-induced Aβ aggregation, exhibiting potent antioxidant activity and good blood-brain barrier (BBB) penetration. Has potential to treat Alzheimer's disease[1]. IC50: 8.9 nM (BuChE)[1].

[1]. Sang Z, et al. Design, Synthesis, and Evaluation of Novel Ferulic Acid Derivatives as Multi-Target-Directed Ligands for the Treatment of Alzheimer's Disease. ACS Chem Neurosci. 2019 Feb 20;10(2):1008-1024.