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ICA 110381
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ICA 110381图片
CAS NO:325457-99-6
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
ICA 110381 (Compound 16) 是一种 KCNQ2/Q3 钾通道开放剂,用于治疗癫痫。
Cas No.325457-99-6
化学名4-chloro-N-(6-chloropyridin-3-yl)benzamide
Canonical SMILESClC1=CC=C(C=C1)C(NC2=CC=C(N=C2)Cl)=O
分子式C12H8Cl2N2O
分子量267.11
溶解度<26.71mg/ml in DMSO;<5.34mg/ml in ethanol
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ICA 110381 (Compound 16) is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. ICA 110381 is a KCNQ2/Q3 agonist (EC50=0.38 μM) as well as KCNQ1 antagonist (IC50=15 μM)[1].

References:
[1]. Amato G, et al. N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med Chem Lett. 2011 Mar 31;2(6):481-4.