| CAS NO: | 348575-88-2 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 50mg | 电议 |
| Cas No. | 348575-88-2 |
| 化学名 | (E)-5-((2,5-dimethyl-1-(pyridin-3-yl)-1H-pyrrol-3-yl)methylene)-4-hydroxythiazole-2(5H)-thione |
| Canonical SMILES | CC(N1C2=CN=CC=C2)=CC(/C([H])=C(S3)\C(O)=NC3=S)=C1C |
| 分子式 | C15H13N3OS2 |
| 分子量 | 315.41 |
| 溶解度 | DMF: 25 mg/ml,DMF:PBS(pH 7.2)(1:6): 0.14 mg/ml,DMSO: 20 mg/ml |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Optovin is an activator of TRPA1 [1]. Transient receptor potential cation channel, subfamily A, member 1 (TRPA1) is an ion channel that involved in signal transduction and growth control. TRPA1 signaling plays an important role in chronic inflammation and neuropathic pain [1]. Optovin is a photoactivator of TRPA1. In dorsal root ganglia (DRG) sensory neurons isolated from mice, optovin significantly activated 33% (35/105) of DRG neurons, which was not occured in the dark. In HEK293T cells transfected with the human TRPA1, optovin activated cells. Optovin activated TRPA1 channels through a photoactivated intermediate that reacted with redox-sensitive cysteine residues in the channel [1]. In wild-type zebrafish embryos, optovin increased light-dependent motor activity with EC50 value of 2 μM. Optovin induced zebrafish respond to 387-nm light stimuli. Optovin acted on sensory neurons and was not dependent on visual pathways for the increase of light-dependent motor activity. In zebrafish with trpa1b mutant, optovin didn’t have effect, which suggested trpa1b is necessary for optovin activity. In adult mice, optovin induced head-shaking behaviors [1]. Reference: |
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