| CAS NO: | 1237744-13-6 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 50mg | 电议 |
| Cas No. | 1237744-13-6 |
| 化学名 | (S,Z)-3-(4-carboxyphenyl)-6-methoxy-2-(3-nitrostyryl)-4-oxo-4,4a-dihydroquinazolin-3-ium |
| Canonical SMILES | O=C1[N+](C2=CC=C(C(O)=O)C=C2)=C(/C=C\C3=CC=CC([N+]([O-])=O)=C3)N=C(C=C4)[C@@H]1C=C4OC |
| 分子式 | C24H17N3O6 |
| 分子量 | 443.41 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | QNZ46 is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist (IC50 values are 3, 6, 229, and >300, >300 μM for NR2D, NR2C, NR2A, NR2B, and GluR1, respectively). IC50 value: 3 μM (for NR2D), 6 μM (for NR2C), 229 μM (for NR2D NR2A)Target: NR2D, NR2C, NR2Ain vitro: QNZ46 is a noncompetitive inhibitor of GluN2C/D containing NMDA receptors. KD and IC50 values for binding and inhibition of GluN1/Glun2D receptors by QNZ46 are 4.9 and 3.9 μM, respectively. QNZ46 does not compete for binding of glutamate or glycine, but QNZ46 receptor binding requires the binding of glutamate to the GluN2 subunit. References: |
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