Orexin A(human,rat,mouse)

立即咨询

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

205640-90-0

包装与价格：

包装	价格(元)
500ug	电议
1mg	电议
5mg	电议

产品介绍

化学性质

Physical Appearance	A crystalline solid
Storage	Desiccate at -20°C
M.Wt	3565.14
Cas No.	205640-90-0
Formula	C₁₅₂H₂₄₇N₄₇O₄₄S₄
Solubility	Soluble to 1 mg/ml in sterile water
Canonical SMILES	CC[C@]([C@@](/N=C(O)/C/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/C/N=C(O)/[C@](/N=C(O)/C/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Orexin A, a 33 amino acid hypothalamic neuropeptide, is an endogenous agonist at orexin-1 and -2 receptors[1]. It play a role in appetite regulation, wakefulness, locomotor activity, hypothalamic-pituitary-adrenal activity, and pain thresholds[2].

Orexin A (10 and 30 mg/kg i.v., 5 min pre-plantar test) increases the latency to thermally stimulated paw contraction to baseline levels. Orexin A (3-30 mg/kg; i.v.; 5 min pre-test) significantly increases the reaction latency of intravenous reactions of 10 and 30 mg/kg[3].

References:

[1]. Rodgers R J, Ishii Y, Halford J C G, et al. Orexins and appetite regulation. Neuropeptides, 2002, 36(5): 303-325 .

[2]. Lang M, Soll R M, Dürrenberger F, et al. Structure-activity studies of orexin A and orexin B at the human orexin 1 and orexin 2 receptors led to orexin 2 receptor selective and orexin 1 receptor preferring ligands. Journal of Medicinal Chemistry, 2004, 47(5): 1153-1160.

[3]. Bingham S, et al. Orexin-A, an hypothalamic peptide with analgesic properties. Pain, 2001, 92(1-2): 81-90.