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Colivelin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Colivelin图片
CAS NO:867021-83-8
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍

化学性质

Physical AppearanceWhite lyophilised solid
StorageStore at -20°C
M.Wt2645.13
Cas No.867021-83-8
FormulaC119H206N32O35
Solubilityinsoluble in DMSO; insoluble in EtOH; ≥15 mg/mL in H2O
Canonical SMILESCC[C@]([C@@](/N=C(O)/[C@](/N=C(O)/C/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/C/N=C(O)/[C@](/N=C(O)/[C@]1([H])CCCN1C([C@](/N=C(O)/[C@]2([H])CCCN2C([C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

资料参考

Colivelin is a brain-penetrant neuroprotective peptide, exhibiting potent long-term capacity against Aβ deposition, synaptic plasticity deficits, and neuronal apoptosis in neurodegenerative disease. Moreover, Colivelin is an activator of STAT3, which can rescue ischemic neuronal death and axonal remodeling by activating JAK/STAT3 signaling. Thus, Colivelin has the potential for the treatment of Alzheimer’s disease and ischemic brain injury.

References:

1. Zhao H, Feng Y, Wei C, et al. Colivelin Rescues Ischemic Neuron and Axons Involving JAK/STAT3 Signaling Pathway. Neuroscience, 2019, 416: 198-206.

2. Chiba T, Yamada M, Hashimoto Y, et al. Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insultsin vitroandin vivo. The Journal of Neuroscience, 2005, 25(44): 10252-10261.

试验操作

Cell experiment:[2]

Cell lines

Mouse primary cortical neurons (PCNs)

Reaction Conditions

100 aM, 1 fM, 10 fM, 100 fM, 1 pM, 10 pM, 100 pM, 1 nM, 10 nM, or 100 nM Colivelin for 16 h incubation

Applications

Colivelin at a concentration of 100 fM completely suppressed neuronal death induced by Aβ1-43. Colivelin was a femtomolar-acting bioactive peptide at least as potent as ADNFin vitro. Furthermore, Colivelin did not lose its neuroprotective activity even at higher concentrations.

Animal experiment:[1]

Animal models

Male C57BL/6 mice, 10 ~ 12 wk of age

Dosage form

1 mg/kg

Once daily by intraperitoneal injection for 6 days

Applications

Colivelin treatment resulted in improved motor and cognitive function over time (from day 1 to day 14 post ischemia and reperfusion), as shown by performance of mNSS, rotarod, and corner turning test. It also reduced lesion volume and improved neurological deficits after middle cerebral artery occlusion.

Note

The technical data provided above is for reference only.

References:

1. Zhao H, Feng Y, Wei C, et al. Colivelin Rescues Ischemic Neuron and Axons Involving JAK/STAT3 Signaling Pathway. Neuroscience, 2019, 416: 198-206.

2. Chiba T, Yamada M, Hashimoto Y, et al. Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insultsin vitroandin vitro. The Journal of Neuroscience, 2005, 25(44): 10252-10261.