Spermidine trihydrochloride

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CAS NO:

334-50-9

包装与价格：

包装	价格(元)
10mM (in 1mL H2O)	电议
100mg	电议

产品介绍

化学性质

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	254.63
Cas No.	334-50-9
Formula	C₇H₁₉N₃·3HCl
Solubility	insoluble in DMSO; insoluble in EtOH; ≥10 mg/mL in H2O
Chemical Name	N1-(3-aminopropyl)butane-1,4-diamine trihydrochloride
Canonical SMILES	NCCCCNCCCN.Cl.Cl.Cl
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Spermidine trihydrochloride is an agonist of theN-methyl-D-aspartate (NMDA) receptor. The NMDA receptor is a ligand-gated ion channel complex with multiple regulatory sites in addition to the glutamate recognition site. Spermidine binds to the polyamine modulatory site of the NMDA receptor, and has been classified as agonists at this site based on their ability to enhance the binding of MK801 (a noncompetitive antagonist of the NMDA receptor). Thus, spermidine potentially enhances the neuroprotective effect of NMDA antagonists.

References:

1. Munir M, Subramaniam S, McGonigle P. Polyamines modulate the neurotoxic effects of NMDA in vivo. Brain Research, 1993, 616(1-2): 163-170.

2. Carvalho FB, Mello CF, Marisco PC, et al. Spermidine decreases Na+, K+-ATPase activity through NMDA receptor and protein kinase G activation in the hippocampus of rats. European Journal of Pharmacology, 2012, 684(1-3): 79-86.

3. Rao TS, Cler JA, Oei EJ, et al. The polyamines, spermine and spermidine, negatively modulate N-methyl-d-aspartate (NMDA) and quisqualate receptor mediated responses in vivo: Cerebellar cyclic GMP measurements. Neurochemistry International, 1990, 16(2): 199-206.

试验操作

Cell experiment:[2]
Cell lines	Hippocampal slices and homogenates from rats
Reaction Conditions	0.05 ~ 10 μM spermidine for 30 min incubation
Applications	Spermidine at the concentrations of 0.5 and 1 μM decreased Na⁺, K⁺-ATPase activity in slices, but not in homogenates. Spermidine also increased NO₂plus NO₃(NOx) levels in slices.
Animal experiment:[3]
Animal models	Male Swiss-Webster mice
Dosage form	200 μg/mouse Intracerebellar injection
Applications	Spermidine at 200 μg/mouse did not alter the basal cGMP level in mouse cerebellum. Moreover, spermidine attenuated responses mediated through NMDA, NMDA-associated glycine receptor and quisqualate receptors. Since spermidine is widely distributed in neural and non-neural tissues, it plays a potential key role in cell differentiation and growth.
Note	The technical data provided above is for reference only.
	References: 1. Munir M, Subramaniam S, McGonigle P. Polyamines modulate the neurotoxic effects of NMDA in vivo. Brain Research, 1993, 616(1-2): 163-170. 2. Carvalho FB, Mello CF, Marisco PC, et al. Spermidine decreases Na⁺, K⁺-ATPase activity through NMDA receptor and protein kinase G activation in the hippocampus of rats. European Journal of Pharmacology, 2012, 684(1-3): 79-86. 3. Rao TS, Cler JA, Oei EJ, et al. The polyamines, spermine and spermidine, negatively modulate N-methyl-d-aspartate (NMDA) and quisqualate receptor mediated responses in vivo: Cerebellar cyclic GMP measurements. Neurochemistry International, 1990, 16(2): 199-206.