| CAS NO: | 443-48-1 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 5g | 电议 |
| 10g | 电议 |
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 171.15 |
| Cas No. | 443-48-1 |
| Formula | C6H9N3O3 |
| Solubility | ≥11.54 mg/mL in EtOH with ultrasonic; ≥3.13 mg/mL in H2O with ultrasonic; ≥8.55 mg/mL in DMSO |
| Chemical Name | 2-(2-methyl-5-nitroimidazol-1-yl)ethanol |
| Canonical SMILES | CC1=NC=C(N1CCO)[N+](=O)[O-] |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Metronidazole is an effective inhibitor of OAT3 with IC50 of 6.51 ± 0.99 μM, Kiof 6.48 μM [1]. Also as a nitroimidazole antibiotic medication, metronidazole is used targeting anaerobic bacteria and protozoa [2].
Human Organ anion/cation transporters (OATs) are important membrane transporters, which are responsible for the cellular influx of drugs in human key tissues. Inhibitors affecting the cellular intake of transporter could make dysfunction of transporters, causing drug-drug interactions (DDIs) and bring poor effect and /or side reactions.
Transport functional assay indicated that Metronidazole potently inhibited the transport activity of OAT3 with IC50 of 6.51 ± 0.99 μM, Kiof 6.48 μM. Metronidazole could also reduce methotrexate influx via OATs and OATP1A2 consistently [1].
Reference:
[1] Lu X, Chan T, Zhu L, et al. The inhibitory effects of eighteen front-line antibiotics on the substrate uptake mediated by human Organic anion/cation transporters Organic anion transporting polypeptides and Oligopeptide transporters in invitro models [J]. European Journal of Pharmaceutical Sciences. 2018, 115(30): 132-143.
[2] Scully BE. Metronidazole. Medical Clinic of North America. 1988, 72(3): 613-621.
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