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DNQX disodium salt
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
DNQX disodium salt图片
CAS NO:1312992-24-7
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
DNQX (FG 9041) disodium salt 是一种喹喔啉衍生物，是一种选择性的、有效的竞争性非 NMDA 谷氨酸受体拮抗剂（对 AMPA、红藻氨酸和 NMDA 受体的 IC50 分别为 0.5、2 和 40 μM）。
Cas No.1312992-24-7
别名6,7-Dinitroquinoxaline-2,3-dione
化学名sodium 6,7-dinitroquinoxaline-2,3-bis(olate)
Canonical SMILES[O-][N+](C1=C(C=C(C(N=C2[O-])=C1)N=C2[O-])[N+]([O-])=O)=O.[Na+].[Na+]
分子式C8H2N4O6Na2
分子量296.1
溶解度5mg/mL in DMSO, 12mg/mL in DMF
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively versus IC50 = 40 μM for NMDA receptors).[1],[2],[3] This compound has been used to specifically target AMPA and kainate receptor responses and thus differentiate from that of NMDA receptors. DNQX does not stimulate a robust long-term potentiation in the hippocampus.[4]

Reference:
[1]. Armstrong, N., and Gouaux, E. Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: Crystal structures of the GluR2 ligand binding core. Neuron 28(1), 165-181 (2000).
[2]. Honoré, T., Davies, S.N., Drejer, J., et al. Quinoxalinediones: Potent competitive non-NMDA glutamate receptor antagonists. Science 241(4866), 701-703 (1988).
[3]. Lee, S.H., Govindaiah, G., and Cox, C.L. Selective excitatory actions of DNQX and CNQX in rat thalamic neurons. J. Neurophysiol. 103(4), 1728-1734 (2010).
[4]. Muller, D., Joly, M., and Lynch, G. Contributions of quisqualate and NMDA receptors to the induction and expression of LTP. Science 242(4886), 1694-1697 (1988).