您好，欢迎来到化工原料网！ [登录] [免费注册]
化工原料网
发布求购
位置：首页 > 产品库 > ML 277
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
ML 277
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
ML 277图片
CAS NO:1401242-74-7
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
ML 277(CID53347902) 是一种新型、有效和选择性的 K(v)7.1 (KCNQ1) 钾通道激活剂，EC50 为 270 nM。
Cas No.1401242-74-7
别名CID-53347902
化学名(R,Z)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carbimidic acid
Canonical SMILESCC1=CC=C(S(N2CCCC[C@]2([H])/C(O)=N/C3=NC(C4=CC=C(OC)C=C4)=CS3)(=O)=O)C=C1
分子式C23H25N3O4S2
分子量471.59
溶解度DMSO: 5 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ML277(CID53347902) is a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270 nM.IC50 value: 270 nM (EC50) [1]Target: K(v)7.1 activatorML277 was shown to be highly selective against other KCNQ channels (>100-fold selectivity versus KCNQ2 and KCNQ4) as well as against the distantly related hERG potassium channel.

References:
[1]. Mattmann ME, et al. Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5936-41.