CAS NO: | 946387-07-1 |
包装 | 价格(元) |
10mg | 电议 |
50mg | 电议 |
500mg | 电议 |
1g | 电议 |
Cas No. | 946387-07-1 |
别名 | 2,4-二氯-N-(异丙基)-N-[2-[(异丙基)氨基]乙基]苯磺酰胺 |
化学名 | 2,4-dichloro-N-isopropyl-N-(2-(isopropylamino)ethyl)benzenesulfonamide |
Canonical SMILES | CC(NCCN(S(C1=C(Cl)C=C(Cl)C=C1)(=O)=O)C(C)C)C |
分子式 | C14H22CL2N2O2S |
分子量 | 353.31 |
溶解度 | ≥ 71 mg/mL in DMSO, ≥ 72 mg/mL in EtOH |
储存条件 | Store at -20℃ |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50s for all three species (hTRPV4: 2.3 μM, mTRPV4: 5.9 μM, rTRPV4: 3.2 μM)[1]. RN-1734 clearly decreases the production of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) without altering the number of olig2-positive cells[2]. RN-1734 (27 hours; 10μM) reverses the increase in the apoptotic rate of oligodendrocytes induced by CM (LPS-activated microglia group) apoptosis[2].RN-1734 (27 hours; 10μM) alleviates CM-induced decreases in CNP[2]. RN-1734 (0.5 μl; microinjector pump; daily for 5 weeks) significantly reverses the decrease in CNP protein and improves myelination in CPZ-induced demyelination mouse[2]. References: |