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Reversan
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Reversan图片
CAS NO:313397-13-6
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
MST-312 是一种端粒酶抑制剂。 MST-312 是绿茶表没食子儿茶素没食子酸酯 (EGCG) 的化学改性衍生物。 MST-312可用于癌症研究,例如多发性骨髓瘤(MM)。
Cas No.313397-13-6
别名CBLC4H10
化学名N-(3-morpholinopropyl)-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide
Canonical SMILESO=C(C1=C(N=C(C2=CC=CC=C2)C=C3C4=CC=CC=C4)N3N=C1)NCCCN5CCOCC5
分子式C26H27N5O2
分子量441.52
溶解度<11.04mg/ml in DMSO
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Reversan (CBLC4H10) is a potent and nontoxic multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (Pgp) inhibitor[1][2].

References:
[1]. Tivnan A, et al. Inhibition of multidrug resistance protein 1 (MRP1) improves chemotherapy drug response in primary and recurrent glioblastoma multiforme. Front Neurosci. 2015 Jun 16;9:218.
[2]. Burkhart CA, et al. Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma. Cancer Res. 2009 Aug 15;69(16):6573-80.