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Blosozumab
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:1132758-87-2
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
Blosozumab (LY2541546) 是一种抗人 sclerostin (SOST) 的抗体抑制剂。Blosozumab 可刺激骨形成并减少骨吸收。Blosozumab 可用于骨质疏松症的研究。
Cas No.1132758-87-2
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Blosozumab (LY2541546) is an anti-Humansclerostin (SOST)antibody inhibitor. Blosozumab stimulates bone formation and reduces bone resorption. Blosozumab can be used in the research of Osteoporosis[1][2].

Blosozumab (1-100 mg/kg, i.v.) shows effects of hyperostosis in rats[1].

Animal Model:Sprague-Dawley rats[2]
Dosage:1, 10, and 100 mg/kg
Administration:Intravenous injection (i.v.), once every 3 days (5-week study) or once weekly (6-month study)
Result:Observed the bone anabolic effects.
Showed significant bleeding and morbidity at 100 mg/kg.
Decreases in the numbers of platelets.
Increased number of bone marrow megakaryocytes at 100 mg/kg.