Danofloxacin Mesylate(CP 76136-27)

Molecular Weight (MW)	453.48
Formula	C19H20FN3O3.CH4O3S
CAS No.	119478-55-6
Storage	-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)	DMSO: <1 mg/mL
Water: 91 mg/mL (200.7 mM)
Ethanol: <1 mg/mL
Solubility (In vivo)	Saline: 30 mg/mL
Synonyms	Synonym: CP 76,136-27; CP-76,136-27; Danofloxacin monomethanesulfonate. Chemical Name: 1-Cyclopropyl-6-fluoro-1,4-dihydro-7-((1S,4S)-5-methyl-2,5-diazabicyclo(2.2.1)hept-2-yl)-4-oxo-3-quinolinecarboxylic acid, monomethanesulfonate InChi Key: APFDJSVKQNSTKF-FXMYHANSSA-N InChi Code: InChI=1S/C19H20FN3O3.CH4O3S/c1-21-7-12-4-11(21)8-22(12)17-6-16-13(5-15(17)20)18(24)14(19(25)26)9-23(16)10-2-3-10;1-5(2,3)4/h5-6,9-12H,2-4,7-8H2,1H3,(H,25,26);1H3,(H,2,3,4)/t11-,12-;/m0./s1 SMILES Code: O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4[C@](C5)([H])CN(C)[C@]5([H])C4)=C3)C1=O)O.CS(=O)(O)=O

Molecular Weight (MW)

453.48

Formula

C19H20FN3O3.CH4O3S

CAS No.

119478-55-6

Storage

-20℃ for 3 years in powder form

-80℃ for 2 years in solvent

Solubility (In vitro)

DMSO: <1 mg/mL

Water: 91 mg/mL (200.7 mM)

Ethanol: <1 mg/mL

Solubility (In vivo)

Saline: 30 mg/mL

Synonyms

Synonym: CP 76,136-27; CP-76,136-27; Danofloxacin monomethanesulfonate.

Chemical Name: 1-Cyclopropyl-6-fluoro-1,4-dihydro-7-((1S,4S)-5-methyl-2,5-diazabicyclo(2.2.1)hept-2-yl)-4-oxo-3-quinolinecarboxylic acid, monomethanesulfonate

InChi Key: APFDJSVKQNSTKF-FXMYHANSSA-N

InChi Code: InChI=1S/C19H20FN3O3.CH4O3S/c1-21-7-12-4-11(21)8-22(12)17-6-16-13(5-15(17)20)18(24)14(19(25)26)9-23(16)10-2-3-10;1-5(2,3)4/h5-6,9-12H,2-4,7-8H2,1H3,(H,25,26);1H3,(H,2,3,4)/t11-,12-;/m0./s1

SMILES Code: O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4[C@](C5)([H])CN(C)[C@]5([H])C4)=C3)C1=O)O.CS(=O)(O)=O

In Vitro	In vitro activity: Danofloxacin is a synthetic antibacterial agent of the fluoroquinolone class, acts principally by the inhibition of bacterial DNA-gyrase, which is necessary for supercoiling of DNA to provide a suitable spatial arrangement of DNA within the bacterial cell. The minimum inhibitory concentration of danofloxacin against 90% (MIC90) of contemporary European and North American field isolates of Pasteurella haemolytica, Pasteurella multocida and Haemophilus somnus, the most important bacterial respiratory pathogens of cattle, is 0.125 μg/ml.
In Vivo	Danofloxacin shows protective dose (PD50) of 0.38, 0.8, 2.42 mg/kg for P. multocida, E. coli and S. choleraesuis in in vivo mouse protection assay.
Animal model	Mice model
Formulation & Dosage	Dissolved in 2.5% or 5% water solution; 0-10 mg/kg; p.o or s.c.
References	J Vet Pharmacol Ther. 1991 Dec;14(4):400-10; J Med Chem. 1992 Feb 21;35(4):611-20.

In Vitro

In vitro activity: Danofloxacin is a synthetic antibacterial agent of the fluoroquinolone class, acts principally by the inhibition of bacterial DNA-gyrase, which is necessary for supercoiling of DNA to provide a suitable spatial arrangement of DNA within the bacterial cell. The minimum inhibitory concentration of danofloxacin against 90% (MIC90) of contemporary European and North American field isolates of Pasteurella haemolytica, Pasteurella multocida and Haemophilus somnus, the most important bacterial respiratory pathogens of cattle, is 0.125 μg/ml.

In Vivo

Danofloxacin shows protective dose (PD50) of 0.38, 0.8, 2.42 mg/kg for P. multocida, E. coli and S. choleraesuis in in vivo mouse protection assay.

Animal model

Mice model

Formulation & Dosage

Dissolved in 2.5% or 5% water solution; 0-10 mg/kg; p.o or s.c.

References

J Vet Pharmacol Ther. 1991 Dec;14(4):400-10; J Med Chem. 1992 Feb 21;35(4):611-20.

CAS NO:	119478-55-6
规格:	≥98%

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议
1g	电议
5g	电议
10g	电议