Propargyl-PEG8-acid

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Propargyl-PEG8-acid

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2055014-94-1

包装与价格：

包装	价格(元)
50mg	电议
100mg	电议

产品介绍

Propargyl-PEG8-acid 是一种 PROTAC 连接桥，属于 PEG 类。Propargyl-PEG8-acid 可用于合成一系列 PROTAC 分子。Propargyl-PEG8-acid 是一种可降解 (cleavable) 的 ADC 连接桥，用于抗体药物结合物 (ADCs) 的合成。这些 ADCs 可用于革兰氏阴性细菌引起的细菌感染。

Cas No.	2055014-94-1
分子式	C₂₀H₃₆O₁₀
分子量	436.49
储存条件	4°C, stored under nitrogen
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Propargyl-PEG8-acid is a PEG-basedPROTAC linkercan be used in the synthesis of PROTACs. Propargyl-PEG8-acid is a cleavableADC linkerused in the synthesis of antibody-drug conjugates (ADCs). The ADCs can be used in bacterial infections caused by Gram-negative bacteria^[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.