Vitamin C

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Vitamin C

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

50-81-7

包装与价格：

包装	价格(元)
10mM (in 1mL DMSO)	电议
1g	电议

产品介绍

化学性质

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	176.12
Cas No.	50-81-7
Formula	C₆H₈O₆
Solubility	≥12.2 mg/mL in EtOH with ultrasonic; ≥5.8 mg/mL in DMSO; ≥57.9 mg/mL in H2O
Chemical Name	(R)-5-((S)-1,2-dihydroxyethyl)-3,4-dihydroxyfuran-2(5H)-one
Canonical SMILES	O[C@@H](CO)[C@H](C(O)=C1O)OC1=O
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Vitamin C, a water-soluble vitamin, typically functions in the prevention and treatment of the common cold, hypersensitivity and viral infection. It has also been used as an auxiliary treatment for patients with cancer [1].

In CT26 murine colon cancer cells, 100 and 200 μg/ml Vitamin C significantly inhibited tumor cell proliferation. When concentrations of Vitamin C exceeded 200 μg/ml, tumor cells underwent apparent apoptosis. At concentrations of 200, 500 and 1000 μg/ml, Vitamin C markedly induced tumor cell apoptosis, in a dose-dependent manner. In addition, synergistic inhibitory effects of vitamin C (200 μg/ml) and Cisplatin (1 mg/ml) against CT26 tumor cells were observed [1].

In CT26 tumor-bearing BALB/c mice, tumor volume substantially decreased in the high-dose group (2, 4 and 6 mg during 8 ~ 11, 14 ~ 17 and 20 ~ 23 d after inoculation, respectively). Significant diminution of 4T1 tumor growth could also be observed following low- (1, 2, 3 and 4 mg during 8 ~ 11, 14 ~ 17, 20 ~ 23 and 26 ~ 29 d after inoculation, respectively) and high-dose (2, 4, 6 and 8 mg during 8 ~ 11, 14 ~ 17, 20 ~ 23 and 26 ~ 29 d after inoculation, respectively) Vitamin C treatment [1].

Reference:

[1]. Wang G, Yin T, Wang Y. In vitro and in vivo assessment of high-dose vitamin C against murine tumors. Experimental and Therapeutic Medicine, 2016, 12(5): 3058-3062.