L-Arginine(hydrochloride)

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1119-34-2

包装与价格：

包装	价格(元)
500mg	电议
1g	电议

产品介绍

化学性质

Storage	Store at -20°C
M.Wt	210.66
Cas No.	1119-34-2
Formula	C₆H₁₅ClN₄O₂
Synonyms	(S)-(+)-Arginine hydrochloride
Solubility	insoluble in EtOH; insoluble in DMSO; ≥72.8 mg/mL in H2O
Chemical Name	(S)-2-amino-5-guanidinopentanoic acid hydrochloride
Canonical SMILES	NC(NCCC[C@H](N)C(O)=O)=N.Cl
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

L-Arginine (hydrochloride) is the biological precursor of NO which serves as an important signal and effector molecule in animals. L-Arginine is a substrate for NO synthase which catalyzes the oxidation of L-arginine to NO and L-citrulline. NO released by vascular endothelial cells results in relaxation of strips of vascular tissue, as well as inhibition of platelet aggregation and platelet adhesion. L-arginine can be utilized by vascular endothelial cells for NO synthesis, and thereby serves as a potent vasodilator.

References:

1. Stuehr DJ. Enzymes of the L-arginine to nitric oxide pathway. Journal of Nutrition, 2004, 134(10 Suppl): 2748S-2751S.

2. Palmer RM, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature, 1988, 333(6174): 664-666.

3. Morikawa E, Moskowitz MA, Huang Z, et al. L-arginine infusion promotes nitric oxide-dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat. Stroke, 1994, 25(2): 429-435.

试验操作

Cell experiment:[2]
Cell lines	Porcine aortic endothelial cells
Reaction Conditions	10 μM L-arginine for 24 h incubation
Applications	Release of NO from the endothelial cells induced by bradykinin and the calcium ionophore A23187 was reversibly enhanced by infusions of L-arginine and L-citrulline, but not D-arginine or other close structural analogues. This enhancement was due to the formation of NO from the terminal guanidino nitrogen atom(s) of L-arginine.
Animal experiment:[3]
Animal models	Normotensive Sprague-Dawley rats and spontaneously hypertensive rats
Dosage form	30 and 300 mg/kg Intravenous (i.v.) administration
Applications	L-Arginine induced dilation of pial arterioles and increased regional cerebral blood flow in normotensive Sprague-Dawley rats. L-Arginine (300 mg/kg, i.v.) also reduced infarction volume by 35% and 28% in normotensive Sprague-Dawley rats and spontaneously hypertensive rats subjected to middle cerebral artery occlusion, respectively.
Note	The technical data provided above is for reference only.
	References: 1. Stuehr DJ. Enzymes of the L-arginine to nitric oxide pathway. Journal of Nutrition, 2004, 134(10 Suppl): 2748S-2751S. 2. Palmer RM, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature, 1988, 333(6174): 664-666. 3. Morikawa E, Moskowitz MA, Huang Z, et al. L-arginine infusion promotes nitric oxide-dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat. Stroke, 1994, 25(2): 429-435.