| 包装 | 价格(元) |
| 5mg | 电议 |
| 25mg | 电议 |
| 100mg | 电议 |
| Storage | Store at -20°C |
| M.Wt | 189.17 |
| Formula | C6H11N3O4 |
| Solubility | Soluble in DMSO |
| Chemical Name | 3-(2-azidoethoxy)-1,1-dihydroxybutan-2-one |
| Canonical SMILES | CC(OCCN=[N+]=[N-])C(C(O)O)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
N3-kethoxal is a small, membrane-permeable probe, which selectively binds to un-paired guanine residues within a cellular environment and then provides a bio-orthogonal handle for click chemistry reactions. Depending on how the azide group is utilized, N3-kethoxal is amenable to various nucleic acid probing applications. The N3-kethoxal platform can be utilized to probe RNA secondary and tertiary structure, map single stranded DNA regions in the genome, explore RNA-RNA interactions, and identify protein-RNA interactions. Compared with current nucleic acid probes, N3-kethoxal exhibits low toxicity, as well as high specificity, resolution, and reproducibility, providing a novel click chemistry platform forin vitroandin vivoanalyses of nucleic acid structure and proximity interactions.
References:
1. Huang J, Zhao R, Mo J, et al. N3-kethoxal-based bioorthogonal intracellular RNA labeling. ChemBioChem, 2021, 22(9): 1559-1562.
2. He C. Novel click chemistry platform forin vivoandin vitroanalysis of nucleic acid structure and proximity interactions. Polsky Center for Entrepreneurship and Innovation, 2019, reference ID: 19-T-037.
3. Weng X, Gong J, Chen Y, et al. Keth-seq for transcriptome-wide RNA structure mapping. Nature Chemical Biology, 2020, 16(5): 489-492.
m.cnreagent.com