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N3-kethoxal
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
N3-kethoxal图片
包装与价格:
包装价格(元)
5mg电议
25mg电议
100mg电议

产品介绍

化学性质

StorageStore at -20°C
M.Wt189.17
FormulaC6H11N3O4
SolubilitySoluble in DMSO
Chemical Name3-(2-azidoethoxy)-1,1-dihydroxybutan-2-one
Canonical SMILESCC(OCCN=[N+]=[N-])C(C(O)O)=O
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

资料参考

N3-kethoxal is a small, membrane-permeable probe, which selectively binds to un-paired guanine residues within a cellular environment and then provides a bio-orthogonal handle for click chemistry reactions. Depending on how the azide group is utilized, N3-kethoxal is amenable to various nucleic acid probing applications. The N3-kethoxal platform can be utilized to probe RNA secondary and tertiary structure, map single stranded DNA regions in the genome, explore RNA-RNA interactions, and identify protein-RNA interactions. Compared with current nucleic acid probes, N3-kethoxal exhibits low toxicity, as well as high specificity, resolution, and reproducibility, providing a novel click chemistry platform forin vitroandin vivoanalyses of nucleic acid structure and proximity interactions.

References:

1. Huang J, Zhao R, Mo J, et al. N3-kethoxal-based bioorthogonal intracellular RNA labeling. ChemBioChem, 2021, 22(9): 1559-1562.

2. He C. Novel click chemistry platform forin vivoandin vitroanalysis of nucleic acid structure and proximity interactions. Polsky Center for Entrepreneurship and Innovation, 2019, reference ID: 19-T-037.

3. Weng X, Gong J, Chen Y, et al. Keth-seq for transcriptome-wide RNA structure mapping. Nature Chemical Biology, 2020, 16(5): 489-492.