| CAS NO: | 565-73-1 |
| 包装 | 价格(元) |
| 5g | 电议 |
| 10g | 电议 |
| 25g | 电议 |
| 50g | 电议 |
| Storage | Store at -20°C |
| M.Wt | 111.03 |
| Cas No. | 565-73-1 |
| Formula | C2H2NNaO3 |
| Solubility | insoluble in EtOH; insoluble in DMSO; ≥11.1 mg/mL in H2O |
| Chemical Name | sodium 2-amino-2-oxoacetate |
| Canonical SMILES | [O-]C(C(N)=O)=O.[Na+] |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Sodium oxamate is a competitive LDHA(actate dehydrogenase A) inhibitor, sodium oxamate is a derivative of pyruvate that inhibits the conversion of pyruvate to lactate via lactate dehydrogenase, thus disrupting glycolysis. Because cancer cells produce a large amount of energy via aerobic glycolysis, sodium oxamate has been studied as an inhibitor of carbohydrate metabolism in various tumors[1,2].
References：
[1]. Anna Z K, De S M M L, Antonio S, et al. Modulation of Cell Metabolic Pathways and Oxidative Stress Signaling Contribute to Acquired Melphalan Resistance in Multiple Myeloma Cells. PLOS ONE, 2015, 10(3): e0119857.
[2]. Cui J, Shi M, Xie D, et al. FOXM1 promotes the warburg effect and pancreatic cancer progression via transactivation of LDHA expression. Clinical Cancer Research, 2014, 20(10): 2595-2606.
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