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EP1013(F1013)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
EP1013(F1013)图片
CAS NO:223568-55-6
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
EP1013 (F1013) (F1013) 是一种广谱 caspase 选择性抑制剂,用于 1 型糖尿病的研究。
Cas No.223568-55-6
别名F1013
Canonical SMILESO=C(O)C[C@H](NC([C@H](C(C)C)NC(OCC1=CC=CC=C1)=O)=O)C(CF)=O
分子式C18H23FN2O6
分子量382.38
溶解度DMSO : ≥ 60 mg/mL (156.91 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

EP1013 is a broad-spectrum caspase selective inhibitor, used in the research of type 1 diabetes.

EP1013 (1, 3, 10 mg/kg) significantly improves marginal islet mass function. Two animals in the 10 mg/kg EP1013 treatment group exhibit primary islet graft nonfunction, but the diabetes reversalrate for this group is not significantly different from the 3 mg/kg EP1013, 1 mg/kg EP1013, or 10 mg/kg zVAD groups. EP1013 therapy enhances functional syngeneic islet mass and promotes longevity of islet graft function[1].

[1]. Emamaullee JA, et al. The caspase selective inhibitor EP1013 augments human islet graft function and longevity in marginal mass islet transplantation in mice. Diabetes. 2008 Jun;57(6):1556-66.