Fusicoccin (Fusicoccin A) 是一种真菌毒素，是特定 14-3-3 蛋白质-蛋白质相互作用的稳定剂。 Fuscoccin 稳定裤子中的 H+-ATPase/14-3-3 复合物，使酶保持在活化状态。 Fusicoccin 还能稳定 14-3-3 蛋白与含有 C 端 14-3-3 识别基序（模式 3 基序）的结合配偶体的相互作用，例如 ERα、GPIbα、TASK3、CTFR 和 p53。 Fusicoccin 可诱导癌细胞凋亡并具有抗癌活性。
| Cas No. | 20108-30-9 |
| 别名 | 壳梭孢(菌)素,Fusicoccin A |
| 化学名 | (1S,4R,5R,6R,6aS,9S,10aR)-3-[(1S)-2-(acetyloxy)-1-methylethyl]-1,2,4,5,6,6a,7,8,9,10a-decahydro-1,5-dihydroxy-9-(methoxymethyl)-6,10a-dimethyldicyclopenta[a,d]cycloocten-4-yl 6-O-(1,1-dimethyl-2-propen-1-yl)-α-D-glucopyranoside, 3-acetate |
| Canonical SMILES | O[C@H]1[C@H](O[C@@]2([H])O[C@H](COC(C)(C)C=C)[C@@H](O)[C@H](OC(C)=O)[C@H]2O)C3=C([C@@H](COC(C)=O)C)C[C@H](O)[C@]3(C)/C=C4[C@](CC[C@@H]\4COC)([H])[C@H]1C |
| 分子式 | C36H56O12 |
| 分子量 | 680.8 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Fusicoccin is a phytotoxin originally isolated from F. amygdali that induces death of tomato plants when used at concentrations ranging from 0.1 to 0.2 μg/ml. Topical administration of fusicoccin to tobacco (N. tabacum), sorghum (S. bicolor), cucumber (C. sativa), lucerne (M. sativa), and pokeweed (P. Americana) induces permanent opening of leaf stomata and wilting. Fusicoccin binds to the preformed complex between plasma membrane H+-ATPase and a 14-3-3 protein in plants to stabilize and activate the enzyme leading to dysregulated solute transport and control of transmembrane electric potential. It also stabilizes eukaryotic 14-3-3 protein interactions with binding partners containing a C-terminal 14-3-3 recognition motif, also known as a mode 3 motif, such as ERα, GPIbα, TASK3, CTFR, and p53 in vitro. Fusicoccin stimulates cortical neurite outgrowth in a 14-3-3 protein-dependent manner (EC50 = 29 μM). In vivo, topical administration of fusicoccin to the injury site reduces collapse and retraction of severed axons in a mouse model of spinal cord injury. |
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