Peramivir Trihydrate(RWJ-270201 BCX-1812)

Molecular Weight (MW)	382.45
Formula	C15H28N4O4.3H2O
CAS No.	1041434-82-5
Storage	-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)	DMSO: <1 mg/mL
Water: <1 mg/mL
Ethanol: <1 mg/mL
SMILES	O[C@H]1[C@]([C@H](C(CC)CC)NC(C)=O)([H])[C@H](NC(N)=N)C[C@@H]1C(O)=O.[H]O.[H]O.[H]O
Synonyms	BCX-1812,RWJ-270201, S-021812; BCX1812; BCX 1812; RWJ 270201; RWJ270201; Peramivir. Brand name: Rapivab; Rapiacta and Peramiflu

Molecular Weight (MW)

382.45

Formula

C15H28N4O4.3H2O

CAS No.

1041434-82-5

Storage

-20℃ for 3 years in powder form

-80℃ for 2 years in solvent

Solubility (In vitro)

DMSO: <1 mg/mL

Water: <1 mg/mL

Ethanol: <1 mg/mL

SMILES

O[C@H]1[C@]([C@H](C(CC)CC)NC(C)=O)([H])[C@H](NC(N)=N)C[C@@H]1C(O)=O.[H]O.[H]O.[H]O

Synonyms

BCX-1812,RWJ-270201, S-021812; BCX1812; BCX 1812; RWJ 270201; RWJ270201; Peramivir. Brand name: Rapivab; Rapiacta and Peramiflu

In Vitro	In vitro activity: N/A Kinase Assay: N/A Cell Assay: N/A
In Vivo	Peramivir protects mice against severe disease outcomes following infection with highly pathogenic avian influenza and multi-dose treatment was efficacious in ferrets. Peramivir combined with Oseltamivir perform better than suboptimal doses of each compound alone to treat influenza infections in mice. Peramivir (30 mg/kg) is effective in promoting the survival of mice infected with systemically replicating H5N1 virus. Peramivir is 30% protective against H1N1 virus in mice at 0.5 mg/kg/d, but ineffective at lower doses when used as monotherapy. Peramivir combined with favipiravir increases the numbers of survivors by 10-50% when the 0.025 mg/kg/d, 0.05 mg/kg/d, and 0.1 mg/kg/d doses of Peramivir are combined with 20 mg/kg/d Favipiravir and when all doses of Peramivir are combined with 40 mg/kg/d Favipiravir. Peramivir combined with favipiravir results in an increase in lifespan, improved body weight and significant reductions in lung hemorrhage score and lung weight in H1N1 infected mice. Peramivir (1 mg/kg/d) combined with Rimantadine (5 mg/kg/d and 10 mg/kg/d) produces weight losses of 1.69 and 0.69, respectively, whereas the combination of 3.0 mg/kg/d Peramivir with 10 and 30 mg/kg/d Rimantadine does not show any weight loss in sub-lethal influenza A (H3N2) virus mouse model.
Animal model	Mice
Formulation & Dosage	0.025 mg/kg/d, 0.05 mg/kg/d, and 0.1 mg/kg/d
References	Virology. 2008 Apr 25;374(1):198-209; Antiviral Res. 2010 Oct;88(1):38-44; Antiviral Res. 2008 Nov;80(2):150-7.

In Vitro

In vitro activity: N/A

Kinase Assay: N/A

Cell Assay: N/A

In Vivo

Peramivir protects mice against severe disease outcomes following infection with highly pathogenic avian influenza and multi-dose treatment was efficacious in ferrets. Peramivir combined with Oseltamivir perform better than suboptimal doses of each compound alone to treat influenza infections in mice. Peramivir (30 mg/kg) is effective in promoting the survival of mice infected with systemically replicating H5N1 virus. Peramivir is 30% protective against H1N1 virus in mice at 0.5 mg/kg/d, but ineffective at lower doses when used as monotherapy. Peramivir combined with favipiravir increases the numbers of survivors by 10-50% when the 0.025 mg/kg/d, 0.05 mg/kg/d, and 0.1 mg/kg/d doses of Peramivir are combined with 20 mg/kg/d Favipiravir and when all doses of Peramivir are combined with 40 mg/kg/d Favipiravir. Peramivir combined with favipiravir results in an increase in lifespan, improved body weight and significant reductions in lung hemorrhage score and lung weight in H1N1 infected mice. Peramivir (1 mg/kg/d) combined with Rimantadine (5 mg/kg/d and 10 mg/kg/d) produces weight losses of 1.69 and 0.69, respectively, whereas the combination of 3.0 mg/kg/d Peramivir with 10 and 30 mg/kg/d Rimantadine does not show any weight loss in sub-lethal influenza A (H3N2) virus mouse model.

Animal model

Mice

Formulation & Dosage

0.025 mg/kg/d, 0.05 mg/kg/d, and 0.1 mg/kg/d

References

Virology. 2008 Apr 25;374(1):198-209; Antiviral Res. 2010 Oct;88(1):38-44; Antiviral Res. 2008 Nov;80(2):150-7.

CAS NO:	1041434-82-5
规格:	≥98%

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议
250mg	电议
500mg	电议