C12 神经酰胺 (d18:1/12:0) (N-Lauroyl-D-erythro-sphingosine) 是一种天然存在的神经酰胺，由 C12 鞘磷脂水解形成。
| Cas No. | 74713-60-3 |
| 别名 | N-月桂酰-D-鞘胺醇,N-Lauroyl-D-erythro-sphingosine; N-Laurylsphingosine |
| Canonical SMILES | OC[C@H](NC(CCCCCCCCCCC)=O)[C@H](O)/C=C/CCCCCCCCCCCCC |
| 分子式 | C30H59NO3 |
| 分子量 | 481.8 |
| 溶解度 | DMF: 22 mg/ml,DMSO: 20 mg/ml,Ethanol: >33 mg/ml,PBS (pH 7.2):<50µ g/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | C12 ceramide is a naturally occurring ceramide that is formed when C12 sphingomyelin is hydrolyzed by acid sphingomyelinase (ASM). It is a substrate for acid ceramidase, an enzyme that has 2- to 12-fold higher activity in fibroblasts from patients with Farber disease, a lipid storage disorder. C12 ceramide is found in the Wharton's jelly, a protective coating that surrounds umbilical cord vessels, of babies born to women with pre-eclampsia. BODIPY C12 ceramide has been used to assess levels of ASM activity in plasma of patients with type A or B Niemann-Pick disease. |
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